Applying increasingly powerful computation to genomics contributes to important medical breakthroughs. On this course, you will discover the basic principles of microbial bioinformatics analysis, and comparative genomics. Using Artemis, a free genome browser, you will find out how to investigate whole bacterial genomes, and through the analysis of bacterial genes and proteins, you will explore the genomic features of pathogens. By the end of this course, you will be able to use genomic data to increase your knowledge of microbial genomes.
- Welcome, Reference genomes and introduction to Artemis
- Genome annotation, GC (guanine-cytosine) content, and data access
- Consolidation and Peer Review Project
This course would benefit those interested in learning how to use tools to investigate bacterial genomes, and acquire bioinformatics skills to evaluate the role of microbial genes in disease. Using analytical tools to access and probe genomes, learners will find out how to perform comparative analyses of genes and their protein products.
By the end of the course, you‘ll be able to…
- Collect, access, and download whole bacterial genomes from public repositories
- Investigate and navigate bacterial genomes and their annotation using Artemis
- Identify genomic regions with low/high GC (guanine-cytosine) content, often associated with virulence
- Perform simple comparative analyses between bacterial genomes